2 October 2013 Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo
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J. of Biomedical Optics, 18(12), 121503 (2013). doi:10.1117/1.JBO.18.12.121503
Abstract
We demonstrate the use of phase-stabilized swept-source optical coherence tomography to assess the propagation of low-amplitude (micron-level) waves induced by a focused air-pulse system in tissue-mimicking phantoms, a contact lens, a silicone eye model, and the mouse cornea in vivo. The results show that the wave velocity can be quantified from the analysis of wave propagation, thereby enabling the estimation of the sample elasticity using the model of surface wave propagation for the tissue-mimicking phantoms. This noninvasive, noncontact measurement technique involves low-force methods of tissue excitation that can be potentially used to assess the biomechanical properties of ocular and other delicate tissues in vivo.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Jiasong Li, Shang Wang, Ravi Kiran Manapuram, Manmohan Singh, Floredes M. Menodiado, Salavat Aglyamov, Stanislav Y. Emelianov, Michael D. Twa, Kirill V. Larin, "Dynamic optical coherence tomography measurements of elastic wave propagation in tissue-mimicking phantoms and mouse cornea in vivo," Journal of Biomedical Optics 18(12), 121503 (2 October 2013). http://dx.doi.org/10.1117/1.JBO.18.12.121503
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KEYWORDS
Cornea

In vivo imaging

Tissues

Optical coherence tomography

Wave propagation

Eye models

Tissue optics

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