8 November 2013 Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography
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Abstract
We propose an integrated method combining low-frequency mechanics with optical imaging to map the shear modulus within the biological tissue. Induced shear wave propagating in tissue is tracked in space and time using phase-sensitive optical coherence tomography (PhS-OCT). Local estimates of the shear-wave speed obtained from tracking results can image the local shear modulus. A PhS-OCT system remotely records depth-resolved, dynamic mechanical waves at an equivalent frame rate of ∼47  kHz with the high spatial resolution. The proposed method was validated by examining tissue-mimicking phantoms made of agar and light scattering material. Results demonstrate that the shear wave imaging can accurately map the elastic moduli of these phantoms.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Shaozhen Song, Shaozhen Song, Zhihong Huang, Zhihong Huang, Thu-Mai Nguyen, Thu-Mai Nguyen, Emily Y. Wong, Emily Y. Wong, Bastien Arnal, Bastien Arnal, Matthew O'Donnell, Matthew O'Donnell, Ruikang K. Wang, Ruikang K. Wang, } "Shear modulus imaging by direct visualization of propagating shear waves with phase-sensitive optical coherence tomography," Journal of Biomedical Optics 18(12), 121509 (8 November 2013). https://doi.org/10.1117/1.JBO.18.12.121509 . Submission:
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