2 December 2013 Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli
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We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Martial H. Geiser, Frederic Truffer, Hugo Evequoz, Hafid Khayi, Benjamin Mottet, Christophe Chiquet, "Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli," Journal of Biomedical Optics 18(12), 127001 (2 December 2013). https://doi.org/10.1117/1.JBO.18.12.127001

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