2 December 2013 Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli
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We describe a device to measure blood perfusion for the human optic nerve head (ONH) based on laser Doppler flowmetry (LDF) with a flicker stimuli of the fovea region. This device is self-aligned for LDF measurements and includes near-infrared pupil observation, green illumination, and observation of the ONH. The optical system of the flowmeter is based on a Schlieren arrangement which collects only photons that encounter multiple scattering and are back-scattered out of the illumination point. LDF measurements are based on heterodyne detection of Doppler shifted back-scattered light. We also describe an automated analysis of the LDF signals which rejects artifacts and false signals such as blinks. By using a Doppler simulator consisting of a lens and a rotating diffusing wheel, we demonstrate that velocity and flow vary linearly with the speed of the wheel. A cohort of 12 healthy subjects demonstrated that flicker stimulation induces an increase of 17.8% of blood flow in the ONH.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Martial H. Geiser, Martial H. Geiser, Frederic Truffer, Frederic Truffer, Hugo Evequoz, Hugo Evequoz, Hafid Khayi, Hafid Khayi, Benjamin Mottet, Benjamin Mottet, Christophe Chiquet, Christophe Chiquet, } "Schlieren laser Doppler flowmeter for the human optical nerve head with the flicker stimuli," Journal of Biomedical Optics 18(12), 127001 (2 December 2013). https://doi.org/10.1117/1.JBO.18.12.127001 . Submission:

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