10 December 2013 Influence of different energy densities of laser phototherapy on oral wound healing
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The aim of the present prospective study was to evaluate the impact of laser phototherapy (LPT) on the healing of oral ulcers. Different power densities were used on oral wounds in Wistar rats (n=72) randomly divided into three groups: control (0  J/cm2), 4  J/cm2 laser, and 20  J/cm2 laser. Ulcers (3 mm in diameter) were made on the dorsum of the tongue with a punch. Irradiation with an indium-gallium-aluminum-phosphide laser (660 nm; output power: 40 mW; spot size: 0.04  cm2) was performed once a day in close contact with the ulcer for 14 consecutive days. A statistically significant acceleration in healing time was found with wounds treated with 4  J/cm2 LPT. Moreover, striking differences were found in the ulcer area, healing percentage, degree of reepithelialization, and collagen deposition. The most significant changes occurred after 5 days of irradiation. Based on the conditions employed in the present study, LPT is capable of accelerating the oral mucosa wound-healing process. Moreover, faster and more organized reepithelialization and tissue healing of the oral mucosa were achieved with an energy density of 4  J/cm2 in comparison to 20  J/cm2.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Vivian Petersen Wagner, Vivian Petersen Wagner, Luise Meurer, Luise Meurer, Marco Antonio Trevizani Martins, Marco Antonio Trevizani Martins, Chris Krebs Danilevicz, Chris Krebs Danilevicz, Alessandra Selinger Magnusson, Alessandra Selinger Magnusson, Márcia Martins Marques, Márcia Martins Marques, Manoel Sant’Ana Filho, Manoel Sant’Ana Filho, Cristiane Helena Squarize, Cristiane Helena Squarize, Manoela Domingues Martinsa, Manoela Domingues Martinsa, } "Influence of different energy densities of laser phototherapy on oral wound healing," Journal of Biomedical Optics 18(12), 128002 (10 December 2013). https://doi.org/10.1117/1.JBO.18.12.128002 . Submission:

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