16 December 2013 Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing loss
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J. of Biomedical Optics, 18(12), 128003 (2013). doi:10.1117/1.JBO.18.12.128003
The primary cause of hearing loss includes damage to cochlear hair cells. Low-level laser therapy (LLLT) has become a popular treatment for damaged nervous systems. Based on the idea that cochlea hair cells and neural cells are from same developmental origin, the effect of LLLT on hearing loss in animal models is evaluated. Hearing loss animal models were established, and the animals were irradiated by 830-nm diode laser once a day for 10 days. Power density of the laser treatment was 900  mW/cm2 , and the fluence was 162 to 194 J. The tympanic membrane was evaluated after LLLT. Thresholds of auditory brainstem responses were evaluated before treatment, after gentamicin, and after 10 days of LLLT. Quantitative scanning electron microscopic (SEM) observations were done by counting remaining hair cells. Tympanic membranes were intact at the end of the experiment. No adverse tissue reaction was found. On SEM images, LLLT significantly increased the number of hair cells in middle and basal turns. Hearing was significantly improved by laser irradiation. After LLLT treatment, both the hearing threshold and hair-cell count significantly improved.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Chung-Ku Rhee, Peijie He, Jae Yun Jung, Jin-Chul Ahn, Phil-Sang Chung, Min Young Lee, Myung-Whan Suh, "Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing loss," Journal of Biomedical Optics 18(12), 128003 (16 December 2013). https://doi.org/10.1117/1.JBO.18.12.128003


Laser therapeutics

Scanning electron microscopy

Fiber lasers

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