20 February 2013 Fabrication of a thin-layer solid optical tissue phantom by a spin-coating method: pilot study
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Solid optical tissue phantoms (OTPs) have been widely used for many purposes. This study introduces a spin-coating method (SCM) to fabricate a thin-layer solid OTP (TSOTP) with epidermal thickness. TSOTPs are fabricated by controlling the spin speed (250 to 2500 rpm), absorber concentration (0.2% to 1.0%), and the number of layers. The results show that the thicknesses of the TSOTPs are homogeneous in the region of interest. The one-layer TSOTP achieves maximum and minimum thicknesses of 65±0.28  μm (250 rpm) and 5.1±0.17  μm (2500 rpm), respectively, decreasing exponentially as a function of the spin speed. The thicknesses of the multilayer TSOTPs increases as a function of the number of layers and are correlated strongly with the spin speed (R 2 0.95 ). The concentration of the OTP mixture does not directly affect the thickness of the TSOTP; however, the absorption coefficients exponentially increase as a function of absorber concentration (R 2 0.98 ). These results suggest that the SCM can be used to fabricate homogeneous TSOTPs with various thicknesses by controlling the spin speed and number of layers. Finally, a double-layer OTP that combines epidermal TSOTP and dermal OTP is manufactured as a preliminary study to investigate the practical feasibility of TSOTPs.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yunjin Bae, Yunjin Bae, Taeyoon Son, Taeyoon Son, Jihoon Park, Jihoon Park, Byungjo Jung, Byungjo Jung, } "Fabrication of a thin-layer solid optical tissue phantom by a spin-coating method: pilot study," Journal of Biomedical Optics 18(2), 025006 (20 February 2013). https://doi.org/10.1117/1.JBO.18.2.025006 . Submission:

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