6 February 2013 Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy
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Abstract
Preterm infants are highly susceptible to ischemic brain injury; consequently, continuous bedside monitoring to detect ischemia before irreversible damage occurs would improve patient outcome. In addition to monitoring cerebral blood flow (CBF), assessing the cerebral metabolic rate of oxygen (CMRO 2 ) would be beneficial considering that metabolic thresholds can be used to evaluate tissue viability. The purpose of this study was to demonstrate that changes in absolute CMRO 2 could be measured by combining diffuse correlation spectroscopy (DCS) with time-resolved near-infrared spectroscopy (TR-NIRS). Absolute CBF was determined using bolus-tracking TR-NIRS to calibrate the DCS measurements. Cerebral venous blood oxygenation (SvO 2 ) was determined by multiwavelength TR-NIRS measurements, the accuracy of which was assessed by directly measuring the oxygenation of sagittal sinus blood. In eight newborn piglets, CMRO 2 was manipulated by varying the anesthetics and by injecting sodium cyanide. No significant differences were found between the two sets of SvO 2 measurements obtained by TR-NIRS or sagittal sinus blood samples and the corresponding CMRO 2 measurements. Bland–Altman analysis showed a mean CMRO 2 difference of 0.0268±0.8340  mL O 2 /100  g/min between the two techniques over a range from 0.3 to 4 mL O 2 /100  g/min .
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Kyle Verdecchia, Mamadou Diop, Ting-Yim Lee, Keith St. Lawrence, "Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy," Journal of Biomedical Optics 18(2), 027007 (6 February 2013). https://doi.org/10.1117/1.JBO.18.2.027007 . Submission:
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