2 May 2013 In vivo diffuse correlation spectroscopy investigation of the ocular fundus
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J. of Biomedical Optics, 18(5), 057001 (2013). doi:10.1117/1.JBO.18.5.057001
Abstract
Diffuse correlation spectroscopy (DCS) measurements in vivo recorded from rabbits’ ocular fundus are presented. Despite the complexity of these ocular tissues, we provide a clear and simple demonstration of the DCS abilities to analyze variations in physiological quantities of clinical interest. Indeed, the reported experimental activities demonstrate that DCS can reveal both choroidal-flow and temperature variations and detect nano- and micro-aggregates in ocular fundus circulation. Such abilities can be of great interest both in fundamental research and practical clinical applications. The proposed measuring system can be useful in: (a) monitoring choroidal blood flow variations, (b) determining the end-point for photo-dynamic therapy and transpupillary thermo therapy and, (c) managing the dye injection and determining an end-point for dye-enhanced photothrombosis. Moreover, it could allow both diagnoses when the presence of nano- and micro-aggregates is related to specific diseases and verifying the effects of nanoparticle injection in nanomedicine. Even though the reported results demonstrate the applicability of DCS to investigate ocular fundus, a detailed and accurate investigation of the limits of detection is beyond the scope of this article.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Stefano Cattini, Giovanni Staurenghi, Antonietta M. Gatti, Luigi Rovati, "In vivo diffuse correlation spectroscopy investigation of the ocular fundus," Journal of Biomedical Optics 18(5), 057001 (2 May 2013). http://dx.doi.org/10.1117/1.JBO.18.5.057001
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KEYWORDS
Blood circulation

In vivo imaging

Data analysis

Spectroscopy

Temperature metrology

Laser therapeutics

Optical coherence tomography

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