2 May 2013 In vivo diffuse correlation spectroscopy investigation of the ocular fundus
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Diffuse correlation spectroscopy (DCS) measurements in vivo recorded from rabbits’ ocular fundus are presented. Despite the complexity of these ocular tissues, we provide a clear and simple demonstration of the DCS abilities to analyze variations in physiological quantities of clinical interest. Indeed, the reported experimental activities demonstrate that DCS can reveal both choroidal-flow and temperature variations and detect nano- and micro-aggregates in ocular fundus circulation. Such abilities can be of great interest both in fundamental research and practical clinical applications. The proposed measuring system can be useful in: (a) monitoring choroidal blood flow variations, (b) determining the end-point for photo-dynamic therapy and transpupillary thermo therapy and, (c) managing the dye injection and determining an end-point for dye-enhanced photothrombosis. Moreover, it could allow both diagnoses when the presence of nano- and micro-aggregates is related to specific diseases and verifying the effects of nanoparticle injection in nanomedicine. Even though the reported results demonstrate the applicability of DCS to investigate ocular fundus, a detailed and accurate investigation of the limits of detection is beyond the scope of this article.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Stefano Cattini, Stefano Cattini, Giovanni Staurenghi, Giovanni Staurenghi, Antonietta M. Gatti, Antonietta M. Gatti, Luigi Rovati, Luigi Rovati, } "In vivo diffuse correlation spectroscopy investigation of the ocular fundus," Journal of Biomedical Optics 18(5), 057001 (2 May 2013). https://doi.org/10.1117/1.JBO.18.5.057001 . Submission:

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