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26 June 2013 Optical identification of subjects at high risk for developing breast cancer
Paola Taroni, Giovanna Quarto, Antonio Pifferi, Francesca Ieva, Anna Maria Paganoni, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu
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Journal of Biomedical Optics, Vol. 18, Issue 6, 060507 (June 2013). https://doi.org/10.1117/1.JBO.18.6.060507
Abstract
A time-domain multiwavelength (635 to 1060 nm) optical mammography was performed on 147 subjects with recent x-ray mammograms available, and average breast tissue composition (water, lipid, collagen, oxy- and deoxyhemoglobin) and scattering parameters (amplitude a and slope b ) were estimated. Correlation was observed between optically derived parameters and mammographic density [Breast Imaging and Reporting Data System (BI-RADS) categories], which is a strong risk factor for breast cancer. A regression logistic model was obtained to best identify high-risk (BI-RADS 4) subjects, based on collagen content and scattering parameters. The model presents a total misclassification error of 12.3%, sensitivity of 69%, specificity of 94%, and simple kappa of 0.84, which compares favorably even with intraradiologist assignments of BI-RADS categories.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Paola Taroni, Giovanna Quarto, Antonio Pifferi, Francesca Ieva, Anna Maria Paganoni, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, and Rinaldo Cubeddu "Optical identification of subjects at high risk for developing breast cancer," Journal of Biomedical Optics 18(6), 060507 (26 June 2013). https://doi.org/10.1117/1.JBO.18.6.060507
Published: 26 June 2013
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Cited by 32 scholarly publications.
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KEYWORDS
Breast
Collagen
Tissue optics
Breast cancer
Scattering
Mammography
Tissues
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