26 June 2013 Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo
Author Affiliations +
J. of Biomedical Optics, 18(6), 060508 (2013). doi:10.1117/1.JBO.18.6.060508
Abstract
Laser speckle imaging is widely used to monitor functional blood perfusion within tissue beds in vivo but traditionally has difficulty visualizing small blood vessels even when the exposure time of the detector is long. We report a simple method that uses the motion contrast of dynamic speckle patterns to noninvasively visualize the distribution of blood flow within tissue beds in vivo. We experimentally demonstrate that the motion contrast can significantly suppress the effect of static scattering, leading to enhanced visibility of the functional blood vessels, including capillaries when compared to the traditional laser speckle contrast imaging.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Rong Liu, Jia Qin, Ruikang K. Wang, "Motion-contrast laser speckle imaging of microcirculation within tissue beds in vivo," Journal of Biomedical Optics 18(6), 060508 (26 June 2013). http://dx.doi.org/10.1117/1.JBO.18.6.060508
JOURNAL ARTICLE
3 PAGES


SHARE
KEYWORDS
Blood circulation

Laser speckle contrast imaging

Scattering

Blood vessels

Capillaries

In vivo imaging

Laser tissue interaction

Back to Top