2 November 2012 Use of Raman spectroscopy in the analysis of nickel allergy
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Abstract
Raman spectra of the skin of subjects with nickel allergy are analyzed and compared to the spectra of healthy subjects to detect possible biochemical differences in the structure of the skin that could help diagnose metal allergies in a noninvasive manner. Results show differences between the two groups of Raman spectra. These spectral differences can be classified using principal component analysis. Based on these findings, a novel computational technique to make a fast evaluation and classification of the Raman spectra of the skin is presented and proposed as a noninvasive technique for the detection of nickel allergy.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Javier Alda, Claudio Castillo-Martinez, Rodrigo Valdes-Rodriguez, Diana Hernández-Blanco, Benjamin Moncada, Francisco J. González, "Use of Raman spectroscopy in the analysis of nickel allergy," Journal of Biomedical Optics 18(6), 061206 (2 November 2012). https://doi.org/10.1117/1.JBO.18.6.061206 . Submission:
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