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18 June 2013 Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts
Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Giovanni Zaccanti
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Journal of Biomedical Optics, Vol. 18, Issue 6, 066014 (June 2013). https://doi.org/10.1117/1.JBO.18.6.066014
Abstract
The design of inhomogeneous phantoms for diffuse optical imaging purposes using totally absorbing objects embedded in a diffusive medium is proposed and validated. From time-resolved and continuous-wave Monte Carlo simulations, it is shown that a given or desired perturbation strength caused by a realistic absorbing inhomogeneity of a certain absorption and volume can be approximately mimicked by a small totally absorbing object of a so-called equivalent black volume (equivalence relation). This concept can be useful in two ways. First, it can be exploited to design realistic inhomogeneous phantoms with different perturbation strengths simply using a set of black objects with different volumes. Further, it permits one to grade physiological or pathological changes on a reproducible scale of perturbation strengths given as equivalent black volumes, thus facilitating the performance assessment of clinical instruments. A set of plots and interpolating functions to derive the equivalent black volume corresponding to a given absorption change is provided. The application of the equivalent black volume concept for grading different optical perturbations is demonstrated for some examples.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, and Giovanni Zaccanti "Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts," Journal of Biomedical Optics 18(6), 066014 (18 June 2013). https://doi.org/10.1117/1.JBO.18.6.066014
Published: 18 June 2013
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Cited by 41 scholarly publications.
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KEYWORDS
Absorption
Diffuse optical imaging
Monte Carlo methods
Sensors
Optical spheres
Scattering
Brain
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