9 July 2013 Dynamic model of thermal reaction of biological tissues to laser-induced fluorescence and photodynamic therapy
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J. of Biomedical Optics, 18(7), 075002 (2013). doi:10.1117/1.JBO.18.7.075002
Abstract
The aim of this work was to evaluate the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed ultraviolet (UV) laser (λ=337  nm ) and a continuous-wave (cw) visible laser beam =632.8  nm ) using Monte Carlo modeling. Finite-element methodology was used for heat transfer simulation. The analysis of the results showed that heat is not localized on the surface, but is collected inside the tissue in lower skin layers. The simulation was made with the pulsed UV laser beam (used as excitation source in laser-induced fluorescence) and the cw visible laser (used in photodynamic therapy treatments), in order to study the possible thermal effects.
© 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)
Alexey Y. Seteikin, Ilya V. Krasnikov, Eleni A. Drakaki, Mersini Makropoulou, "Dynamic model of thermal reaction of biological tissues to laser-induced fluorescence and photodynamic therapy," Journal of Biomedical Optics 18(7), 075002 (9 July 2013). http://dx.doi.org/10.1117/1.JBO.18.7.075002
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KEYWORDS
Skin

Tissues

Monte Carlo methods

Natural surfaces

Photodynamic therapy

Laser induced fluorescence

Temperature metrology

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