Two-photon excited quantum dots as energy donors for photosensitizer chlorin e6

Artiom Skripka; Jurga Valanciunaite; Gediminas Dauderis; Vilius Poderys; Reda Kubiliute; Ricardas Rotomskis

doi:10.1117/1.JBO.18.7.078002

Abstract

The excitation-related problems in photodynamic therapy of cancer might be solved by combining two-photon (TP) irradiation and quantum dots (QDs) as effective energy donors for conventional photosensitizers (PS). Here, it is demonstrated for the first time that QD–chlorin e₆ (Ce₆ ) complex formed due to the hydrophobic interaction between Ce ₆ molecules and lipid coating of QDs can be effectively excited via TP irradiation at 1030 nm, which spectrally coincides with the biological tissue optical window. TP absorption cross-section for free QDs and Ce₆at 1030 nm was 3325 and 13 Goeppert-Mayer, respectively. Upon TP excitation of QD−Ce₆ solution, the fluorescence band of bound Ce ₆ molecules was observed via energy transfer from excited QDs. Increasing concentration of Ce 6 resulted in quenching of the photoluminescence of QDs and an increase in the fluorescence intensity of bound Ce₆ molecules. These intensity changes coincided well with those observed upon single-photon excitation of QD−Ce ⁶ solution when QDs alone are excited. The efficiency of energy transfer in QD−Ce₆ complex upon TP excitation was about 80% (QD∶Ce ⁶ 1∶5 ). These results indicate that the effective excitation of PS with a low TP absorption cross-section is possible in such type noncovalent complexes via energy transfer from TP excited QDs.

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Artiom Skripka, Artiom Skripka, Jurga Valanciunaite, Jurga Valanciunaite, Gediminas Dauderis, Gediminas Dauderis, Vilius Poderys, Vilius Poderys, Reda Kubiliute, Reda Kubiliute, Ricardas Rotomskis, Ricardas Rotomskis, } "Two-photon excited quantum dots as energy donors for photosensitizer chlorin e6," Journal of Biomedical Optics 18(7), 078002 (17 July 2013). https://doi.org/10.1117/1.JBO.18.7.078002 . Submission:

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