9 January 2014 Deep-tissue light delivery via optrode arrays
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We establish performance characteristics of needle-type waveguides in three-dimensional array architectures as light delivery interfaces into deep tissue for applications, such as optogenetic and infrared (IR) neural stimulation. A single optrode waveguide achieves as high as 90% transmission efficiency, even at tissue depths <1  mm . Throughout the visible and near-IR spectrum, the effective light attenuation through the waveguide is ∼3 orders of magnitude smaller than attenuation in tissue/water, as confirmed by both simulation and experimental results. Light emission profiles from the optrode tips into tissue were also measured. Beam widths of 70 to 150 μm and full-angle divergence ranging from 13 to 40 deg in tissue can be achieved. These beam characteristics satisfy a wide range of requirements for targeted illumination in neural stimulation.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Tanya Vanessa F. Abaya, Tanya Vanessa F. Abaya, Mohit Diwekar, Mohit Diwekar, Steve Blair, Steve Blair, Prashant Tathireddy, Prashant Tathireddy, Loren Rieth, Loren Rieth, Florian Solzbacher, Florian Solzbacher, } "Deep-tissue light delivery via optrode arrays," Journal of Biomedical Optics 19(1), 015006 (9 January 2014). https://doi.org/10.1117/1.JBO.19.1.015006 . Submission:

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