1 October 2014 Laser line scanning for fluorescence reflectance imaging: a phantom study and in vivo validation of the enhancement of contrast and resolution
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Abstract
Intraoperative fluorescence imaging in reflectance geometry is an attractive imaging modality to noninvasively monitor fluorescence-targeted tumors. In some situations, this kind of imaging suffers from poor resolution due to the diffusive nature of photons in tissue. The objective of the proposed technique is to tackle this limitation. It relies on the scanning of the medium with a laser line illumination and the acquisition of images at each position of excitation. The detection scheme proposed takes advantage of the stack of images acquired to enhance the resolution and the contrast of the final image. The experimental protocol is described to fully understand why we overpass the classical limits and validate the scheme on tissue-like phantoms and
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Frederic Fantoni, Lionel Hervé, Vincent Poher, Sylvain Gioux, Jérôme I. Mars, Jean-Marc Dinten, "Laser line scanning for fluorescence reflectance imaging: a phantom study and in vivo validation of the enhancement of contrast and resolution," Journal of Biomedical Optics 19(10), 106003 (1 October 2014). https://doi.org/10.1117/1.JBO.19.10.106003
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