Low coherence interferometry approach for aiding fine needle aspiration biopsies

Ernest W. Chang; Joseph A. Gardecki; Martha B. Pitman; Eric Wilsterman; Ankit H. Patel; Guillermo J. Tearney M.D.; Nicusor V. Iftimia

doi:10.1117/1.JBO.19.11.116005

6 November 2014 Low coherence interferometry approach for aiding fine needle aspiration biopsies

Ernest W. Chang, Joseph A. Gardecki, Martha B. Pitman, Eric Wilsterman, Ankit H. Patel, Guillermo J. Tearney M.D., Nicusor V. Iftimia

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Journal of Biomedical Optics, Vol. 19, Issue 11, 116005 (November 2014). https://doi.org/10.1117/1.JBO.19.11.116005

Abstract

We present portable preclinical low-coherence interference (LCI) instrumentation for aiding fine needle aspiration biopsies featuring the second-generation LCI-based biopsy probe and an improved scoring algorithm for tissue differentiation. Our instrument and algorithm were tested on 38 mice with cultured tumor mass and we show the specificity, sensitivity, and positive predictive value of tumor detection of over 0.89, 0.88, and 0.96, respectively.

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Ernest W. Chang, Joseph A. Gardecki, Martha B. Pitman, Eric Wilsterman, Ankit H. Patel, Guillermo J. Tearney M.D., and Nicusor V. Iftimia "Low coherence interferometry approach for aiding fine needle aspiration biopsies," Journal of Biomedical Optics 19(11), 116005 (6 November 2014). https://doi.org/10.1117/1.JBO.19.11.116005

Published: 6 November 2014

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