24 December 2014 Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking
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Abstract
We demonstrate the in vivo assessment of human scars by parametric imaging of birefringence using polarization-sensitive optical coherence tomography (PS-OCT). Such in vivo assessment is subject to artifacts in the detected birefringence caused by scattering from blood vessels. To reduce these artifacts, we preprocessed the PS-OCT data using a vascular masking technique. The birefringence of the remaining tissue regions was then automatically quantified. Results from the scars and contralateral or adjacent normal skin of 13 patients show a correspondence of birefringence with scar type: the ratio of birefringence of hypertrophic scars to corresponding normal skin is 2.2±0.2 (mean±standard deviation), while the ratio of birefringence of normotrophic scars to normal skin is 1.1±0.4. This method represents a new clinically applicable means for objective, quantitative human scar assessment.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Peijun Gong, Peijun Gong, Lixin Chin, Lixin Chin, Shaghayegh Es’haghian, Shaghayegh Es’haghian, Yih Miin Liew, Yih Miin Liew, Fiona M. Wood, Fiona M. Wood, David D. Sampson, David D. Sampson, Robert A. McLaughlin, Robert A. McLaughlin, } "Imaging of skin birefringence for human scar assessment using polarization-sensitive optical coherence tomography aided by vascular masking," Journal of Biomedical Optics 19(12), 126014 (24 December 2014). https://doi.org/10.1117/1.JBO.19.12.126014 . Submission:
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