12 February 2014 Photoacoustic thermography of tissue
Author Affiliations +
J. of Biomedical Optics, 19(2), 026003 (2014). doi:10.1117/1.JBO.19.2.026003
Photoacoustic (PA) techniques can measure temperature in biological tissues because PA signal amplitude is sensitive to tissue temperature. So far, temperature-measuring PA techniques have focused on sensing of temperature changes at a single position. In this work, we photoacoustically measured spatial distribution of temperature in deep tissue. By monitoring the temperature at a single position using a thermocouple, the relationship between the PA signal amplitude and the actual temperature was determined. The relationship was then used to translate a PA image into a temperature map. This study showed that it is possible to calibrate the system for the temperature range of hyperthermia using single-point measurements over a smaller temperature range. Our experimental results showed a precision of −0.8±0.4°C (mean±standard error ) in temperature measurement, and a spatial resolution as fine as 1.0 mm. PA techniques can be potentially applied to monitor temperature distribution deep in tissue during hyperthermia treatment of cancer.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Haixin Ke, Stephen Tai, Lihong V. Wang, "Photoacoustic thermography of tissue," Journal of Biomedical Optics 19(2), 026003 (12 February 2014). https://doi.org/10.1117/1.JBO.19.2.026003

Temperature metrology

Tissue optics



Photoacoustic spectroscopy

Spatial resolution


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