Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography

Myeong Jin Ju; Jun Geun Shin; Sujin Hoshi; Yoshiaki Yasuno; Byeong Ha Lee; Shuo Tang; Tae Joong Eom

doi:10.1117/1.JBO.19.3.030503

6 March 2014 Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography

Myeong Jin Ju, Jun Geun Shin, Sujin Hoshi, Yoshiaki Yasuno, Byeong Ha Lee, Shuo Tang, Tae Joong Eom

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Journal of Biomedical Optics, Vol. 19, Issue 3, 030503 (March 2014). https://doi.org/10.1117/1.JBO.19.3.030503

Abstract

In this study, polarization-sensitive optical coherence tomography (PS-OCT) capable of providing polarization contrasts such as phase retardation and degree of polarization uniformity (DOPU) was used for visualizing human meibomian glands (MGs) and investigating morphological characteristics of them. Especially, with the help of the DOPU contrast, MGs were exclusively extracted from the volumetric OCT image. In vivo PS-OCT measurements were performed on the upper eyelids of different age groups. From these measurements, different age-dependent aspects of the MG structure were also observed. Based on these observations, it can be inferred that the PS-OCT system has the potential for clinical diagnosis and investigation of MG-related dry eye diseases like MG dysfunction (MGD) and acinar atrophy.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Myeong Jin Ju, Jun Geun Shin, Sujin Hoshi, Yoshiaki Yasuno, Byeong Ha Lee, Shuo Tang, and Tae Joong Eom "Three-dimensional volumetric human meibomian gland investigation using polarization-sensitive optical coherence tomography," Journal of Biomedical Optics 19(3), 030503 (6 March 2014). https://doi.org/10.1117/1.JBO.19.3.030503

Published: 6 March 2014

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