10 April 2014 High-purity separation of cancer cells by optically induced dielectrophoresis
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Abstract
Detecting and concentrating cancer cells in peripheral blood is of great importance for cancer diagnosis and prognosis. Optically induced dielectrophoresis (ODEP) can achieve high resolution and low optical intensities, and the electrode pattern can be dynamically changed by varied light patterns. By changing the projected light pattern, it is demonstrated to separate high-purity gastric cancer cell lines. Traditionally, the purity of cancer cell isolation by negative selection is 0.9% to 10%; by positive selection it is 50% to 62%. An ODEP technology is proposed to enhance the purity of cancer cell isolation to about 77%.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Hsiu-Hsiang Chen, Hsiu-Hsiang Chen, Mai-Wei Lin, Mai-Wei Lin, Wan-Ting Tien, Wan-Ting Tien, Chin-Pen Lai, Chin-Pen Lai, Kuo-Yao Weng, Kuo-Yao Weng, Ching-Huai Ko, Ching-Huai Ko, Chun-Chuan Lin, Chun-Chuan Lin, Jyh-Chern Chen, Jyh-Chern Chen, Kuo-Tung Tiao, Kuo-Tung Tiao, Tse-Ching Chen, Tse-Ching Chen, Shin-Cheh Chen, Shin-Cheh Chen, Ta-Sen Yeh, Ta-Sen Yeh, Chieh-Fang Cheng, Chieh-Fang Cheng, } "High-purity separation of cancer cells by optically induced dielectrophoresis," Journal of Biomedical Optics 19(4), 045002 (10 April 2014). https://doi.org/10.1117/1.JBO.19.4.045002 . Submission:
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