10 April 2014 Double-pass Mach–Zehnder fiber interferometer pH sensor
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J. of Biomedical Optics, 19(4), 047002 (2014). doi:10.1117/1.JBO.19.4.047002
A biocompatible fiber-optic pH sensor based on a unique double-pass Mach–Zehnder interferometer is proposed. pH responsive poly(2-hydroxyethyl methacrylate-co-2-(dimethylamino)ethyl methacrylate) hydrogel coating on the fiber swells/deswells in response to local pH, leading to refractive index changes that manifest as shifting of interference dips in the optical spectrum. The pH sensor is tested in spiked phosphate buffer saline and demonstrates high sensitivity of 1.71  nm/pH , pH 0.004 limit of detection with good responsiveness, repeatability, and stability. The proposed sensor has been successfully applied in monitoring the media pH in cell culture experiments to investigate the relationship between pH and cancer cell growth.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhi Qiang Tou, Chi Chiu Chan, Jesmond Hong, Shermaine Png, Khay Ming Tan Eddie, Terence Aik Huang Tan, "Double-pass Mach–Zehnder fiber interferometer pH sensor," Journal of Biomedical Optics 19(4), 047002 (10 April 2014). https://doi.org/10.1117/1.JBO.19.4.047002

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