23 May 2014 Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment
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Abstract
While more than 90% of cancer deaths are due to metastases, our ability to detect circulating tumor cells (CTCs) is limited by low numbers of these cells in the blood and factors confounding specificity of detection. We propose a magnetic enrichment and detection technique for detecting CTCs with high specificity. We targeted both magnetic and surface-enhanced Raman scattering (SERS) nanoparticles to cancer cells. Only cells that are dual-labeled with both kinds of nanoparticles demonstrate an increasing SERS signal over time due to magnetic trapping.
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
Wei Shi, Wei Shi, Robert J. Paproski, Robert J. Paproski, Ronald B. Moore, Ronald B. Moore, Roger Zemp, Roger Zemp, } "Detection of circulating tumor cells using targeted surface-enhanced Raman scattering nanoparticles and magnetic enrichment," Journal of Biomedical Optics 19(5), 056014 (23 May 2014). https://doi.org/10.1117/1.JBO.19.5.056014 . Submission:
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