14 May 2014 Monitoring of the action of drugs in melanoma cells by dynamic laser speckle
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Abstract
This work presents the development of a protocol based on the dynamic laser speckle designed to monitor the reaction of cancer cells of line MEL-RC08 to the application of the drug Colcemid in two different concentrations: 0.2 and 0.4  μg/mL . The protocol was designed using the forward scattering approach with an He-Ne laser of 632.8 nm illuminating the samples, a control, and two variations of Colcemid, being monitored along 8 h. The data were analyzed numerically in the time and in the frequency domain, and the results presented the ability of the technique to monitor the action of the drug, particularly Colcemid (0.4  μg/mL ).
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Rolando J. González-Peña, Roberto A. Braga, Rosa M. Cibrián, Rosario Salvador-Palmer, Rosario Gil-Benso, Teresa San Miguel, "Monitoring of the action of drugs in melanoma cells by dynamic laser speckle," Journal of Biomedical Optics 19(5), 057008 (14 May 2014). https://doi.org/10.1117/1.JBO.19.5.057008 . Submission:
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