Initial results of finger imaging using photoacoustic computed tomography

Peter van Es; Samir K. Biswas; Hein J. Bernelot Moens; Wiendelt Steenbergen; Srirang Manohar

doi:10.1117/1.JBO.19.6.060501

2 June 2014 Initial results of finger imaging using photoacoustic computed tomography

Peter van Es, Samir K. Biswas, Hein J. Bernelot Moens, Wiendelt Steenbergen, Srirang Manohar

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 6, 060501 (June 2014). https://doi.org/10.1117/1.JBO.19.6.060501

Abstract

We present a photoacoustic computed tomography investigation on a healthy human finger, to image blood vessels with a focus on vascularity across the interphalangeal joints. The cross-sectional images were acquired using an imager specifically developed for this purpose. The images show rich detail of the digital blood vessels with diameters between 100 μm and 1.5 mm in various orientations and at various depths. Different vascular layers in the skin including the subpapillary plexus could also be visualized. Acoustic reflections on the finger bone of photoacoustic signals from skin were visible in sequential slice images along the finger except at the location of the joint gaps. Not unexpectedly, the healthy synovial membrane at the joint gaps was not detected due to its small size and normal vascularization. Future research will concentrate on studying digits afflicted with rheumatoid arthritis to detect the inflamed synovium with its heightened vascularization, whose characteristics are potential markers for disease activity.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Peter van Es, Samir K. Biswas, Hein J. Bernelot Moens, Wiendelt Steenbergen, and Srirang Manohar "Initial results of finger imaging using photoacoustic computed tomography," Journal of Biomedical Optics 19(6), 060501 (2 June 2014). https://doi.org/10.1117/1.JBO.19.6.060501

Published: 2 June 2014

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KEYWORDS

Blood vessels

Photoacoustic tomography

Visualization

Imaging systems

Skin

Bone

Photoacoustic imaging

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