27 June 2014 Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media
Author Affiliations +
Abstract
We present a coupled forward-adjoint Monte Carlo (cFAMC) method to determine the spatially resolved sensitivity distributions produced by optical interrogation of three-dimensional (3-D) tissue volumes. We develop a general computational framework that computes the spatial and angular distributions of the forward-adjoint light fields to provide accurate computations in mesoscopic tissue volumes. We provide full computational details of the cFAMC method and provide results for low- and high-scattering tissues probed using a single pair of optical fibers. We examine the effects of source-detector separation and orientation on the sensitivity distributions and consider how the degree of angular discretization used in the 3-D tissue model impacts the accuracy of the resulting absorption sensitivity profiles. We discuss the value of such computations for optical imaging and the design of optical measurements.
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Adam R. Gardner, Adam R. Gardner, Carole K. Hayakawa, Carole K. Hayakawa, Vasan Venugopalan, Vasan Venugopalan, } "Coupled forward-adjoint Monte Carlo simulation of spatial-angular light fields to determine optical sensitivity in turbid media," Journal of Biomedical Optics 19(6), 065003 (27 June 2014). https://doi.org/10.1117/1.JBO.19.6.065003 . Submission:
JOURNAL ARTICLE
13 PAGES


SHARE
Back to Top