Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

R. Andrew Wall; Jennifer K. Barton

doi:10.1117/1.JBO.19.6.067002

3 June 2014 Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

R. Andrew Wall, Jennifer K. Barton

Author Affiliations +

Journal of Biomedical Optics, Vol. 19, Issue 6, 067002 (June 2014). https://doi.org/10.1117/1.JBO.19.6.067002

Abstract

A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope’s capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

Citation Download Citation

R. Andrew Wall and Jennifer K. Barton "Oblique incidence reflectometry: optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system," Journal of Biomedical Optics 19(6), 067002 (3 June 2014). https://doi.org/10.1117/1.JBO.19.6.067002

Published: 3 June 2014

ACCESS THE FULL ARTICLE

JOURNAL ARTICLE
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY