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4 July 2014 Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography
Pei Ma, Yves T. Wang, Shi Gu, Michiko Watanabe, Michael W. Jenkins, Andrew M. Rollins
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Journal of Biomedical Optics, Vol. 19, Issue 7, 076004 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076004
Abstract
Optical mapping (OM) of cardiac electrical activity conventionally collects information from a three-dimensional (3-D) surface as a two-dimensional (2-D) projection map. When applied to measurements of the embryonic heart, this method ignores the substantial and complex curvature of the heart surface, resulting in significant errors when calculating conduction velocity, an important electrophysiological parameter. Optical coherence tomography (OCT) is capable of imaging the 3-D structure of the embryonic heart and accurately characterizing the surface topology. We demonstrate an integrated OCT/OM imaging system capable of simultaneous conduction mapping and 3-D structural imaging. From these multimodal data, we obtained 3-D activation maps and corrected conduction velocity maps of early embryonic quail hearts. 3-D correction eliminates underestimation bias in 2-D conduction velocity measurements, therefore enabling more accurate measurements with less experimental variability. The integrated system will also open the door to correlate the structure and electrophysiology, thereby improving our understanding of heart development.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Pei Ma, Yves T. Wang, Shi Gu, Michiko Watanabe, Michael W. Jenkins, and Andrew M. Rollins "Three-dimensional correction of conduction velocity in the embryonic heart using integrated optical mapping and optical coherence tomography," Journal of Biomedical Optics 19(7), 076004 (4 July 2014). https://doi.org/10.1117/1.JBO.19.7.076004
Published: 4 July 2014
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Cited by 15 scholarly publications.
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KEYWORDS
Heart
Optical coherence tomography
3D image processing
Imaging systems
Velocity measurements
3D metrology
System integration
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