Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

Fabrizio Martelli; Paola Di Ninni; Giovanni Zaccanti; Davide Contini; Lorenzo Spinelli; Alessandro Torricelli; Rinaldo Cubeddu; Heidrun Wabnitz; Mikhail Mazurenka; Rainer Macdonald; Angelo Sassaroli; Antonio Pifferi

doi:10.1117/1.JBO.19.7.076011

14 July 2014 Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Heidrun Wabnitz, Mikhail Mazurenka, Rainer Macdonald, Angelo Sassaroli, Antonio Pifferi

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Journal of Biomedical Optics, Vol. 19, Issue 7, 076011 (July 2014). https://doi.org/10.1117/1.JBO.19.7.076011

Abstract

We present the experimental implementation and validation of a phantom for diffuse optical imaging based on totally absorbing objects for which, in the previous paper [J. Biomed. Opt.18(6), 066014, (2013)], we have provided the basic theory. Totally absorbing objects have been manufactured as black polyvinyl chloride (PVC) cylinders and the phantom is a water dilution of intralipid-20% as the diffusive medium and India ink as the absorber, filled into a black scattering cell made of PVC. By means of time-domain measurements and of Monte Carlo simulations, we have shown the reliability, the accuracy, and the robustness of such a phantom in mimicking typical absorbing perturbations of diffuse optical imaging. In particular, we show that such a phantom can be used to generate any absorption perturbation by changing the volume and position of the totally absorbing inclusion.

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Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Heidrun Wabnitz, Mikhail Mazurenka, Rainer Macdonald, Angelo Sassaroli, and Antonio Pifferi "Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation," Journal of Biomedical Optics 19(7), 076011 (14 July 2014). https://doi.org/10.1117/1.JBO.19.7.076011

Published: 14 July 2014

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