23 July 2014 Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals
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Abstract
A label-free and array-based optical liquid-crystal (LC) immunodetection technique for the detection of CA125 antigen, a protein biomarker most frequently used for ovarian cancer detection, was demonstrated with a nematic LC with larger birefringence (Δn) to promote sensitivity in detecting biomolecules. The LC-based immunodetection offers an alternative and sensitive approach for the detection of biomarker proteins, with the potential of replacing conventional immunoassays used in biochemical studies and clinical laboratories.
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Hui-Wen Su, Hui-Wen Su, Yun-Han Lee, Yun-Han Lee, Mon-Juan Lee, Mon-Juan Lee, Yi-Chiang Hsu, Yi-Chiang Hsu, Wei Lee, Wei Lee, } "Label-free immunodetection of the cancer biomarker CA125 using high-Δn liquid crystals," Journal of Biomedical Optics 19(7), 077006 (23 July 2014). https://doi.org/10.1117/1.JBO.19.7.077006 . Submission:
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