4 August 2014 Autofluorescence imaging device for real-time detection and tracking of pathogenic bacteria in a mouse skin wound model: preclinical feasibility studies
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Abstract
Bacterial infection significantly impedes wound healing. Clinical diagnosis of wound infections is subjective and suboptimal, in part because bacteria are invisible to the naked eye during clinical examination. Moreover, bacterial infection can be present in asymptomatic patients, leading to missed opportunities for diagnosis and treatment. We developed a prototype handheld autofluorescence (AF) imaging device (Portable Real-time Optical Detection, Identification and Guidance for Intervention—PRODIGI) to noninvasively visualize and measure bacterial load in wounds in real time. We conducted preclinical pilot studies in an established nude mouse skin wound model inoculated with bioluminescent
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yichao C. Wu, Yichao C. Wu, Iris Kulbatski, Iris Kulbatski, Philip J. Medeiros, Philip J. Medeiros, Azusa Maeda, Azusa Maeda, Jiachuan Bu, Jiachuan Bu, Lizhen Xu, Lizhen Xu, Yonghong Chen, Yonghong Chen, Ralph S. DaCosta, Ralph S. DaCosta, } "Autofluorescence imaging device for real-time detection and tracking of pathogenic bacteria in a mouse skin wound model: preclinical feasibility studies," Journal of Biomedical Optics 19(8), 085002 (4 August 2014). https://doi.org/10.1117/1.JBO.19.8.085002 . Submission:
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