7 August 2014 Label-free real-time imaging of myelination in the <italic<Xenopus laevis</italic< tadpole by <italic<in vivo</italic< stimulated Raman scattering microscopy
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J. of Biomedical Optics, 19(8), 086005 (2014). doi:10.1117/1.JBO.19.8.086005
Abstract
The myelin sheath plays an important role as the axon in the functioning of the neural system, and myelin degradation is a hallmark pathology of multiple sclerosis and spinal cord injury. Electron microscopy, fluorescent microscopy, and magnetic resonance imaging are three major techniques used for myelin visualization. However, microscopic observation of myelin in living organisms remains a challenge. Using a newly developed stimulated Raman scattering microscopy approach, we report noninvasive, label-free, real-time
© 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Chun-Rui Hu, Delong Zhang, Mikhail N. Slipchenko, Ji-Xin Cheng, Bing Hu, "Label-free real-time imaging of myelination in the <italic<Xenopus laevis</italic< tadpole by <italic<in vivo</italic< stimulated Raman scattering microscopy," Journal of Biomedical Optics 19(8), 086005 (7 August 2014). http://dx.doi.org/10.1117/1.JBO.19.8.086005
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KEYWORDS
Axons

In vivo imaging

Microscopy

Nerve

Signal processing

Imaging systems

Image segmentation

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