Light propagation in tissues with controlled optical properties

Valery V. Tuchin; Irina L. Maksimova; Dmitry A. Zimnyakov; Irina L. Kon; Albert H. Mavlyutov; Alexey A. Mishin

doi:10.1117/12.281502

1 October 1997 Light propagation in tissues with controlled optical properties

Valery V. Tuchin, Irina L. Maksimova, Dmitry A. Zimnyakov, Irina L. Kon, Albert H. Mavlyutov, Alexey A. Mishin

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Journal of Biomedical Optics, Vol. 2, Issue 4, (October 1997). https://doi.org/10.1117/12.281502

Abstract

Theoretical and computer modeling approaches, such as Mie theory, radiative transfer theory, diffusion wavecorrelation spectroscopy, and Monte Carlo simulation were used to analyze tissue optics during a process ofoptical clearing due to refractive index matching. Continuous wave transmittance and forward scatteringmeasurements as well as intensity correlation experiments were used to monitor tissue structural and optical properties. As a control, tissue samples of the human sclera were taken. Osmotically active solutions, such as Trazograph, glucose, and polyethylene glycol, were used as chemicals. A characteristic time response of human scleral optical clearing the range 3 to 10 min was determined. The diffusion coefficients describing the permeability of the scleral samples to Trazograph were experimentally estimated; the average value was D_T≈(0.9±0.5)×10^-5 cm²/s. The results are general and can be used to describe many other fibrous tissues.

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Valery V. Tuchin, Irina L. Maksimova, Dmitry A. Zimnyakov, Irina L. Kon, Albert H. Mavlyutov, and Alexey A. Mishin "Light propagation in tissues with controlled optical properties," Journal of Biomedical Optics 2(4), (1 October 1997). https://doi.org/10.1117/12.281502

Published: 1 October 1997

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KEYWORDS

Tissues

Sclera

Refractive index

Scattering

Light scattering

Diffusion

Collagen

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