20 January 2015 Multimodal imaging of cutaneous wound tissue
Author Affiliations +
J. of Biomedical Optics, 20(1), 016016 (2015). doi:10.1117/1.JBO.20.1.016016
Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject’s upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject’s lower extremity and the healing process was continuously monitored. Our
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Shiwu Zhang, Surya Gnyawali, Jiwei Huang, Wenqi Ren, Gayle Gordillo, Chandan K. Sen, Ronald Xu, "Multimodal imaging of cutaneous wound tissue," Journal of Biomedical Optics 20(1), 016016 (20 January 2015). https://doi.org/10.1117/1.JBO.20.1.016016


Wound healing

Imaging systems

Multimodal imaging



Hyperspectral imaging


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Proceedings of SPIE (February 27 2014)
Hyperspectral imaging of ischemic wounds
Proceedings of SPIE (February 02 2012)
Multimodal imaging of ischemic wounds
Proceedings of SPIE (December 11 2012)

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