20 January 2015 Multimodal imaging of cutaneous wound tissue
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Abstract
Quantitative assessment of wound tissue ischemia, perfusion, and inflammation provides critical information for appropriate detection, staging, and treatment of chronic wounds. However, few methods are available for simultaneous assessment of these tissue parameters in a noninvasive and quantitative fashion. We integrated hyperspectral, laser speckle, and thermographic imaging modalities in a single-experimental setup for multimodal assessment of tissue oxygenation, perfusion, and inflammation characteristics. Algorithms were developed for appropriate coregistration between wound images acquired by different imaging modalities at different times. The multimodal wound imaging system was validated in an occlusion experiment, where oxygenation and perfusion maps of a healthy subject’s upper extremity were continuously monitored during a postocclusive reactive hyperemia procedure and compared with standard measurements. The system was also tested in a clinical trial where a wound of three millimeters in diameter was introduced on a healthy subject’s lower extremity and the healing process was continuously monitored. Our
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Shiwu Zhang, Shiwu Zhang, Surya Gnyawali, Surya Gnyawali, Jiwei Huang, Jiwei Huang, Wenqi Ren, Wenqi Ren, Gayle Gordillo, Gayle Gordillo, Chandan K. Sen, Chandan K. Sen, Ronald Xu, Ronald Xu, } "Multimodal imaging of cutaneous wound tissue," Journal of Biomedical Optics 20(1), 016016 (20 January 2015). https://doi.org/10.1117/1.JBO.20.1.016016 . Submission:
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