22 January 2015 In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography
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Abstract
Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Li Lin, Li Lin, Jun Xia, Jun Xia, Terence T. W. Wong, Terence T. W. Wong, Lei Li, Lei Li, Lihong V. Wang, Lihong V. Wang, } "In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography," Journal of Biomedical Optics 20(1), 016019 (22 January 2015). https://doi.org/10.1117/1.JBO.20.1.016019 . Submission:
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