21 October 2015 All-plastic miniature fluorescence microscope for point-of-care readout of bead-based bioassays
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Abstract
A number of new platforms have been developed for multiplexed bioassays that rely on imaging targeted fluorescent beads labeled with different fluorescent dyes. We developed a compact, low-cost three-dimensional printed fluorescence microscope that can be used as a detector for mutiplexed, bead-based assays to support point-of-care applications. Images obtained with the microscope were analyzed to differentiate multiple analytes in a single sample with a comparable limit of detection to commercially available macroscopic assay platforms.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Alessandra Forcucci, Alessandra Forcucci, Michal Emanuel Pawlowski, Michal Emanuel Pawlowski, Zachary Crannell, Zachary Crannell, Ina Pavlova, Ina Pavlova, Rebecca Richards-Kortum, Rebecca Richards-Kortum, Tomasz S. Tkaczyk, Tomasz S. Tkaczyk, } "All-plastic miniature fluorescence microscope for point-of-care readout of bead-based bioassays," Journal of Biomedical Optics 20(10), 105010 (21 October 2015). https://doi.org/10.1117/1.JBO.20.10.105010 . Submission:
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