5 November 2015 Differences in forward angular light scattering distributions between M1 and M2 macrophages
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The ability to distinguish macrophage subtypes noninvasively could have diagnostic potential in cancer, atherosclerosis, and diabetes, where polarized M1 and M2 macrophages play critical and often opposing roles. Current methods to distinguish macrophage subtypes rely on tissue biopsy. Optical imaging techniques based on light scattering are of interest as they can be translated into biopsy-free strategies. Because mitochondria are relatively strong subcellular light scattering centers, and M2 macrophages are known to have enhanced mitochondrial biogenesis compared to M1, we hypothesized that M1 and M2 macrophages may have different angular light scattering profiles. To test this, we developed an
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
David L. Halaney, David L. Halaney, Aydin Zahedivash, Aydin Zahedivash, Jennifer E. Phipps, Jennifer E. Phipps, Tianyi Wang, Tianyi Wang, Jordan Dwelle, Jordan Dwelle, Claude Jourdan Le Saux, Claude Jourdan Le Saux, Reto Asmis, Reto Asmis, Thomas E. Milner, Thomas E. Milner, Marc D. Feldman, Marc D. Feldman, } "Differences in forward angular light scattering distributions between M1 and M2 macrophages," Journal of Biomedical Optics 20(11), 115002 (5 November 2015). https://doi.org/10.1117/1.JBO.20.11.115002 . Submission:

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