Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise

Brad Henry; Mingjun Zhao; Yu Shang; Timothy Uhl; D. Travis Thomas; Eleftherios S. Xenos; Sibu P. Saha; Guoqiang Yu

doi:10.1117/1.JBO.20.12.125006

23 December 2015 Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise

Brad Henry; Mingjun Zhao; Yu Shang; Timothy Uhl; D. Travis Thomas; Eleftherios S. Xenos; Sibu P. Saha; Guoqiang Yu

Author Affiliations +

J. of Biomedical Optics, 20(12), 125006 (2015). https://doi.org/10.1117/1.JBO.20.12.125006

Abstract

Occlusion calibrations and gating techniques have been recently applied by our laboratory for continuous and absolute diffuse optical measurements of forearm muscle hemodynamics during handgrip exercises. The translation of these techniques from the forearm to the lower limb is the goal of this study as various diseases preferentially affect muscles in the lower extremity. This study adapted a hybrid near-infrared spectroscopy and diffuse correlation spectroscopy system with a gating algorithm to continuously quantify hemodynamic responses of medial gastrocnemius during plantar flexion exercises in 10 healthy subjects. The outcomes from optical measurement include oxy-, deoxy-, and total hemoglobin concentrations, blood oxygen saturation, and relative changes in blood flow (rBF) and oxygen consumption rate (rV˙O₂). We calibrated rBF and rV˙O₂ profiles with absolute baseline values of BF and V˙O₂ obtained by venous and arterial occlusions, respectively. Results from this investigation were comparable to values from similar studies. Additionally, significant correlation was observed between resting local muscle BF measured by the optical technique and whole limb BF measured concurrently by a strain gauge venous plethysmography. The extensive hemodynamic and metabolic profiles during exercise will allow for future comparison studies to investigate the diagnostic value of hybrid technologies in muscles affected by disease.

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Brad Henry, Brad Henry, Mingjun Zhao, Mingjun Zhao, Yu Shang, Yu Shang, Timothy Uhl, Timothy Uhl, D. Travis Thomas, D. Travis Thomas, Eleftherios S. Xenos, Eleftherios S. Xenos, Sibu P. Saha, Sibu P. Saha, Guoqiang Yu, Guoqiang Yu, } "Hybrid diffuse optical techniques for continuous hemodynamic measurement in gastrocnemius during plantar flexion exercise," Journal of Biomedical Optics 20(12), 125006 (23 December 2015). https://doi.org/10.1117/1.JBO.20.12.125006 . Submission:

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