3 February 2015 Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation
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Abstract
We demonstrate the use of a modified Rayleigh–Lamb frequency equation in conjunction with noncontact optical coherence elastography to quantify the viscoelastic properties of the cornea. Phase velocities of air-pulse-induced elastic waves were extracted by spectral analysis and used for calculating the Young’s moduli of the samples using the Rayleigh–Lamb frequency equation (RLFE). Validation experiments were performed on 2% agar phantoms (n=3) and then applied to porcine corneas (n=3) in situ. The Young’s moduli of the porcine corneas were estimated to be ∼60  kPa with a shear viscosity ∼0.33  Pa·s. The results demonstrate that the RLFE is a promising method for noninvasive quantification of the corneal biomechanical properties and may potentially be useful for clinical ophthalmological applications.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Zhaolong Han, Zhaolong Han, Salavat R. Aglyamov, Salavat R. Aglyamov, Jiasong Li, Jiasong Li, Manmohan Singh, Manmohan Singh, Shang Wang, Shang Wang, Srilatha Vantipalli, Srilatha Vantipalli, Chen Wu, Chen Wu, Chih-hao Liu, Chih-hao Liu, Michael D. Twa, Michael D. Twa, Kirill V. Larin, Kirill V. Larin, } "Quantitative assessment of corneal viscoelasticity using optical coherence elastography and a modified Rayleigh–Lamb equation," Journal of Biomedical Optics 20(2), 020501 (3 February 2015). https://doi.org/10.1117/1.JBO.20.2.020501 . Submission:
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