4 February 2015 Promotion of neural sprouting using low-level green light-emitting diode phototherapy
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Abstract
We irradiated neuroblastoma SH-SY5Y cell line with low-level light-emitting diode (LED) illumination at a visible wavelength of 520 nm (green) and intensity of 100  mW/cm2. We captured and analyzed the cell morphology before LED treatment, immediately after, and 12 and 24 h after treatment. Our study demonstrated that LED illumination increases the amount of sprouting dendrites in comparison to the control untreated cells. This treatment also resulted in more elongated cells after treatment in comparison to the control cells and higher levels of expression of a differentiation related gene. This result is a good indication that the proposed method could serve in phototherapy treatment for increasing sprouting and enhancing neural network formation.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Noa Alon, Noa Alon, Hamootal Duadi, Hamootal Duadi, Ortal Cohen, Ortal Cohen, Tamar Samet, Tamar Samet, Neta Zilony, Neta Zilony, Hadas Schori, Hadas Schori, Orit Shefi, Orit Shefi, Zeev Zalevsky, Zeev Zalevsky, } "Promotion of neural sprouting using low-level green light-emitting diode phototherapy," Journal of Biomedical Optics 20(2), 020502 (4 February 2015). https://doi.org/10.1117/1.JBO.20.2.020502 . Submission:
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