10 March 2015 Drop coating deposition Raman spectroscopy of blood plasma for the detection of colorectal cancer
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Abstract
We have recently applied the technique of drop coating deposition Raman (DCDR) spectroscopy for colorectal cancer (CRC) detection using blood plasma. The aim of this study was to develop a more convenient and stable method based on blood plasma for noninvasive CRC detection. Significant differences are observed in DCDR spectra between healthy (n=105) and cancer (n=75) plasma from 15 CRC patients and 21 volunteers, particularly in the spectra that are related to proteins, nucleic acids, and β-carotene. The multivariate analysis principal components analysis and the linear discriminate analysis, together with leave-one-out, cross validation were used on DCDR spectra and yielded a sensitivity of 100% (75/75) and specificity of 98.1% (103/105) for detection of CRC. This study demonstrates that DCDR spectroscopy of blood plasma associated with multivariate statistical algorithms has the potential for the noninvasive detection of CRC.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Pengpeng Li, Pengpeng Li, Changshui Chen, Changshui Chen, Xiaoyuan Deng, Xiaoyuan Deng, Hua Mao, Hua Mao, Shaoqin Jin, Shaoqin Jin, } "Drop coating deposition Raman spectroscopy of blood plasma for the detection of colorectal cancer," Journal of Biomedical Optics 20(3), 037004 (10 March 2015). https://doi.org/10.1117/1.JBO.20.3.037004 . Submission:
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