13 April 2015 Blood typing using microstructured waveguide smart cuvette
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J. of Biomedical Optics, 20(4), 040503 (2015). doi:10.1117/1.JBO.20.4.040503
We introduce a sensitive method that allows one to distinguish positive and negative agglutination reactions used for blood typing and determination of Rh affinity with a high precision. The method is based on the unique properties of photonic crystal waveguides, i.e., microstructured waveguides (MSWs). The transmission spectrum of an MSW smart cuvette filled by a specific or nonspecific agglutinating serum depends on the scattering, refractive, and absorptive properties of the blood probe. This concept was proven in the course of a laboratory clinical study. The obtained ratio of the spectral-based discrimination parameter for positive and negative reactions (I+/I−) was found to be 16 for standard analysis and around 2 for used sera with a weak activity.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Anastasiya A. Zanishevskaya, Andrey A. Shuvalov, Yulia S. Skibina, Valery V. Tuchin, "Blood typing using microstructured waveguide smart cuvette," Journal of Biomedical Optics 20(4), 040503 (13 April 2015). https://doi.org/10.1117/1.JBO.20.4.040503

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