20 April 2015 Organosilicon phantom for photoacoustic imaging
Author Affiliations +
Abstract
Photoacoustic imaging is an emerging technique. Although commercially available photoacoustic imaging systems currently exist, the technology is still in its infancy. Therefore, the design of stable phantoms is essential to achieve semiquantitative evaluation of the performance of a photoacoustic system and can help optimize the properties of contrast agents. We designed and developed a polydimethylsiloxane (PDMS) phantom with exceptionally fine geometry; the phantom was tested using photoacoustic experiments loaded with the standard indocyanine green dye and compared to an agar phantom pattern through polyethylene glycol-gold nanorods. The linearity of the photoacoustic signal with the nanoparticle number was assessed. The signal-to-noise ratio and contrast were employed as image quality parameters, and enhancements of up to 50 and up to 300%, respectively, were measured with the PDMS phantom with respect to the agar one. A tissue-mimicking (TM)-PDMS was prepared by adding TiO2 and India ink; photoacoustic tests were performed in order to compare the signal generated by the TM-PDMS and the biological tissue. The PDMS phantom can become a particularly promising tool in the field of photoacoustics for the evaluation of the performance of a PA system and as a model of the structure of vascularized soft tissues.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Cinzia Avigo, Nicole Di Lascio, Paolo Armanetti, Claudia Kusmic, Lucia Cavigli, Fulvio Ratto, Sandro Meucci, Cecilia Masciullo, Marco Cecchini, Roberto Pini, Francesco Faita, Luca Menichetti, "Organosilicon phantom for photoacoustic imaging," Journal of Biomedical Optics 20(4), 046008 (20 April 2015). https://doi.org/10.1117/1.JBO.20.4.046008 . Submission:
JOURNAL ARTICLE
7 PAGES


SHARE
Back to Top