Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Jianwei Cao; Bilal Khan; Nathan Hervey; Fenghua Tian; Mauricio R. Delgado; Nancy J. Clegg; Linsley Smith; Heather Roberts; Kirsten Tulchin-Francis; Angela Shierk; Laura Shagman; Duncan MacFarlane; Hanli Liu; George Alexandrakis

doi:10.1117/1.JBO.20.4.046009

21 April 2015 Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy

Jianwei Cao, Bilal Khan, Nathan Hervey, Fenghua Tian, Mauricio R. Delgado, Nancy J. Clegg, Linsley Smith, Heather Roberts, Kirsten Tulchin-Francis, Angela Shierk, Laura Shagman, Duncan MacFarlane, Hanli Liu, George Alexandrakis

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Journal of Biomedical Optics, Vol. 20, Issue 4, 046009 (April 2015). https://doi.org/10.1117/1.JBO.20.4.046009

Abstract

Sensorimotor cortex plasticity induced by constraint-induced movement therapy (CIMT) in six children (10.2±2.1 years old) with hemiplegic cerebral palsy was assessed by functional near-infrared spectroscopy (fNIRS). The activation laterality index and time-to-peak/duration during a finger-tapping task and the resting-state functional connectivity were quantified before, immediately after, and 6 months after CIMT. These fNIRS-based metrics were used to help explain changes in clinical scores of manual performance obtained concurrently with imaging time points. Five age-matched healthy children (9.8±1.3 years old) were also imaged to provide comparative activation metrics for normal controls. Interestingly, the activation time-to-peak/duration for all sensorimotor centers displayed significant normalization immediately after CIMT that persisted 6 months later. In contrast to this improved localized activation response, the laterality index and resting-state connectivity metrics that depended on communication between sensorimotor centers improved immediately after CIMT, but relapsed 6 months later. In addition, for the subjects measured in this work, there was either a trade-off between improving unimanual versus bimanual performance when sensorimotor activation patterns normalized after CIMT, or an improvement occurred in both unimanual and bimanual performance but at the cost of very abnormal plastic changes in sensorimotor activity.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Jianwei Cao, Bilal Khan, Nathan Hervey, Fenghua Tian, Mauricio R. Delgado, Nancy J. Clegg, Linsley Smith, Heather Roberts, Kirsten Tulchin-Francis, Angela Shierk, Laura Shagman, Duncan MacFarlane, Hanli Liu, and George Alexandrakis "Evaluation of cortical plasticity in children with cerebral palsy undergoing constraint-induced movement therapy based on functional near-infrared spectroscopy," Journal of Biomedical Optics 20(4), 046009 (21 April 2015). https://doi.org/10.1117/1.JBO.20.4.046009

Published: 21 April 2015

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