6 March 2015 Towards a comprehensive understanding of brain machinery by correlative microscopy
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Abstract
Unraveling the complexity of brain structure and function is the biggest challenge of contemporary science. Due to their flexibility, optical techniques are the key to exploring this intricate network. However, a single imaging technique can reveal only a small part of this machinery due to its inherent multilevel organization. To obtain a more comprehensive view of brain functionality, complementary approaches have been combined. For instance, brain activity was monitored simultaneously on different spatiotemporal scales with functional magnetic resonance imaging and calcium imaging. On the other hand, dynamic information on the structural plasticity of neuronal networks has been contextualized in a wider framework combining two-photon and light-sheet microscopy. Finally, synaptic features have been revealed on previously
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Anna Letizia Allegra Mascaro, Anna Letizia Allegra Mascaro, Ludovico Silvestri, Ludovico Silvestri, Leonardo Sacconi, Leonardo Sacconi, Francesco S. Pavone, Francesco S. Pavone, } "Towards a comprehensive understanding of brain machinery by correlative microscopy," Journal of Biomedical Optics 20(6), 061105 (6 March 2015). https://doi.org/10.1117/1.JBO.20.6.061105 . Submission:
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