CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 20 > Issue 6 > Article
Open Access
7 April 2015 Photodynamic therapy: a review of applications in neurooncology and neuropathology
Anatoly B. Uzdensky, Elena V. Berezhnaya, Vera D. Kovaleva, Marya A. Neginskaya, Mikhail Rudkovskii, Svetlana Sharifulina
Author Affiliations +
Journal of Biomedical Optics, Vol. 20, Issue 6, 061108 (April 2015). https://doi.org/10.1117/1.JBO.20.6.061108
Abstract
Photodynamic therapy (PDT) effect is a promising adjuvant modality for diagnosis and treatment of brain cancer. It is of importance that the bright fluorescence of most photosensitizers provides visualization of brain tumors. This is successfully used for fluorescence-guided tumor resection according to the principle “to see and to treat.” Non-oncologic application of PDT effect for induction of photothrombotic infarct of the brain tissue is a well-controlled and reproducible stroke model, in which a local brain lesion is produced in the predetermined brain area. Since normal neurons and glial cells may also be damaged by PDT and this can lead to unwanted neurological consequences, PDT effects on normal neurons and glial cells should be comprehensively studied. We overviewed the current literature data on the PDT effect on a range of signaling and epigenetic proteins that control various cell functions, survival, necrosis, and apoptosis. We hypothesize that using cell-specific inhibitors or activators of some signaling proteins, one can selectively protect normal neurons and glia, and simultaneously exacerbate photodynamic damage of malignant gliomas.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Anatoly B. Uzdensky, Elena V. Berezhnaya, Vera D. Kovaleva, Marya A. Neginskaya, Mikhail Rudkovskii, and Svetlana Sharifulina "Photodynamic therapy: a review of applications in neurooncology and neuropathology," Journal of Biomedical Optics 20(6), 061108 (7 April 2015). https://doi.org/10.1117/1.JBO.20.6.061108
Published: 7 April 2015
JOURNAL ARTICLE
 7 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 14 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Photodynamic therapy
Neurons
Glia
Tumors
Brain
Proteins
Cell death
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top