Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking

Qinqin Zhang; Yanping Huang; Thomas Zhang; Sophie Kubach; Lin An; Michal Laron; Utkarsh Sharma; Ruikang K. Wang

doi:10.1117/1.JBO.20.6.066008

23 June 2015 Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking

Qinqin Zhang, Yanping Huang, Thomas Zhang, Sophie Kubach, Lin An, Michal Laron, Utkarsh Sharma, Ruikang K. Wang

Author Affiliations +

Journal of Biomedical Optics, Vol. 20, Issue 6, 066008 (June 2015). https://doi.org/10.1117/1.JBO.20.6.066008

Abstract

Optical coherence tomography (OCT)-based optical microangiography (OMAG) is a high-resolution, noninvasive imaging technique capable of providing three-dimensional in vivo blood flow visualization within microcirculatory tissue beds in the eye. Although the technique has demonstrated early clinical utility by imaging diseased eyes, its limited field of view (FOV) and the sensitivity to eye motion remain the two biggest challenges for the widespread clinical use of the technology. Here, we report the results of retinal OMAG imaging obtained from a Zeiss Cirrus 5000 spectral domain OCT system with motion tracking capability achieved by a line scan ophthalmoscope (LSO). The tracking LSO is able to guide the OCT scanning, which minimizes the effect of eye motion in the final results. We show that the tracking can effectively correct the motion artifacts and remove the discontinuities and distortions of vascular appearance due to microsaccade, leading to almost motion-free OMAG angiograms with good repeatability and reliability. Due to the robustness of the tracking LSO, we also show the montage scan protocol to provide unprecedented wide field retinal OMAG angiograms. We experimentally demonstrate a 12×16 mm² retinal OMAG angiogram acquired from a volunteer, which is the widest FOV retinal vasculature imaging up to now in the community.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Qinqin Zhang, Yanping Huang, Thomas Zhang, Sophie Kubach, Lin An, Michal Laron, Utkarsh Sharma, and Ruikang K. Wang "Wide-field imaging of retinal vasculature using optical coherence tomography-based microangiography provided by motion tracking," Journal of Biomedical Optics 20(6), 066008 (23 June 2015). https://doi.org/10.1117/1.JBO.20.6.066008

Published: 23 June 2015

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