Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy

Maciej S. Wróbel; Malgorzata Jedrzejewska-Szczerska; Stanislaw Galla; Leszek Piechowski; Miroslaw Sawczak; Alexey P. Popov; Alexander V. Bykov; Valery V. Tuchin; Adam Cenian

doi:10.1117/1.JBO.20.8.085003

11 August 2015 Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy

Maciej S. Wróbel, Malgorzata Jedrzejewska-Szczerska, Stanislaw Galla, Leszek Piechowski, Miroslaw Sawczak, Alexey P. Popov, Alexander V. Bykov, Valery V. Tuchin, Adam Cenian

Author Affiliations +

J. of Biomedical Optics, 20(8), 085003 (2015). https://doi.org/10.1117/1.JBO.20.8.085003

Abstract

Skin lesions are commonly treated using laser heating. However, the introduction of new devices into clinical practice requires evaluation of their performance. This study presents the application of optical phantoms for assessment of a newly developed 975-nm pulsed diode laser system for dermatological purposes. Such phantoms closely mimic the absorption and scattering of real human skin (although not precisely in relation to thermal conductivity and capacitance); thus, they can be used as substitutes for human skin for approximate evaluation of laser heating efficiency in an almost real environment. Thermographic imaging was applied to measure the spatial and temporal temperature distributions on the surface of laser-irradiated phantoms. The study yielded results of heating with regard to phantom thickness and absorption, as well as laser settings. The methodology developed can be used in practice for preclinical evaluations of laser treatment for dermatology.

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Maciej S. Wróbel, Maciej S. Wróbel, Malgorzata Jedrzejewska-Szczerska, Malgorzata Jedrzejewska-Szczerska, Stanislaw Galla, Stanislaw Galla, Leszek Piechowski, Leszek Piechowski, Miroslaw Sawczak, Miroslaw Sawczak, Alexey P. Popov, Alexey P. Popov, Alexander V. Bykov, Alexander V. Bykov, Valery V. Tuchin, Valery V. Tuchin, Adam Cenian, Adam Cenian, } "Use of optical skin phantoms for preclinical evaluation of laser efficiency for skin lesion therapy," Journal of Biomedical Optics 20(8), 085003 (11 August 2015). https://doi.org/10.1117/1.JBO.20.8.085003 . Submission:

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